APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy

Authors

• George Lau
• Ming-Lung Yu
• Grace Wong
• Alexander Thompson
• Hasmik Ghazinian
• Jin-Lin Hou
• Teerha Piratvisuth
• Ji-Dong Jia
• Masashi Mizokami
• Gregory Cheng
• Guo-Feng Chen
• Zhen-Wen Liu
• Oidov Baatarkhuu
• Ann Lii Cheng
• Woon Leung Ng
• Patrick Lau
• Tony Mok
• Jer-Ming Chang
• Saeed Hamid
• A. Kadir Dokmeci
• Rino A. Gani
• Diana A. Payawal
• Pierce Chow
• Joong-Won Park
• Simone Strasser
• Rosmawaiti Mohamed
• Khin Maung Win
• Tanwandee Tawesak
• Shiv Kumar Sarin
• Masao Omata

Document Type

Article

Publication Date

1-1-2021

Abstract

Background & Aim Hepatitis B reactivation related to the use of immunosuppressive therapy remains a major cause of liver-related morbidity and mortality in hepatitis B endemic Asia-Pacific region. This clinical practice guidelines aim to assist clinicians in all disciplines involved in the use of immunosuppressive therapy to effectively prevent and manage hepatitis B reactivation. Methods All publications related to hepatitis B reactivation with the use of immunosuppressive therapy since 1975 were reviewed. Advice from key opinion leaders in member countries/administrative regions of Asian-Pacific Association for the study of the liver was collected and synchronized. Immunosuppressive therapy was risk-stratified according to its reported rate of hepatitis B reactivation. Recommendations We recommend the necessity to screen all patients for hepatitis B prior to the initiation of immunosuppressive therapy and to administer pre-emptive nucleos(t)ide analogues to those patients with a substantial risk of hepatitis and acute-on-chronic liver failure due to hepatitis B reactivation.

Keywords

APASL, Hepatitis B reactivation, Immunosuppressive therapy, Guideline

Publication Title

Hepatology International

Recommended Citation

Lau, George; Yu, Ming-Lung; Wong, Grace; Thompson, Alexander; Ghazinian, Hasmik; Hou, Jin-Lin; Piratvisuth, Teerha; Jia, Ji-Dong; Mizokami, Masashi; Cheng, Gregory; Chen, Guo-Feng; Liu, Zhen-Wen; Baatarkhuu, Oidov; Cheng, Ann Lii; Ng, Woon Leung; Lau, Patrick; Mok, Tony; Chang, Jer-Ming; Hamid, Saeed; Dokmeci, A. Kadir; Gani, Rino A.; Payawal, Diana A.; Chow, Pierce; Park, Joong-Won; Strasser, Simone; Mohamed, Rosmawaiti; Win, Khin Maung; Tawesak, Tanwandee; Sarin, Shiv Kumar; and Omata, Masao, "APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy" (2021). Research Publications (2021 to 2025). 9947.
https://knova.um.edu.my/research_publications_2021_2025/9947

Divisions

ummc

Volume

15

Issue

5

Publisher

Springer Verlag

Publisher Location

ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES