Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
Document Type
Article
Publication Date
4-1-2022
Abstract
This work presents a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidines. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of substituted dihydro-1,2,4]triazolo1,5-a]pyrimidines were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of the current methodology include short reaction time, wide substrate-scope, and use of a metal-free heterogeneous organocatalyst, simple work-up process.
Keywords
Porous material, Solid-phase synthesis, Heterogeneous catalysis, Multicomponent reactions, Sustainable chemistry
Divisions
nanocat
Funders
High Impact Research Grant Universiti of Malaya [Grant No: NANOCAT RU001-2018]
Publication Title
Polycyclic Aromatic Compounds
Volume
42
Issue
3
Publisher
Taylor & Francis
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND