Design and synthesis of multipotent antioxidants for functionalization of iron oxide nanoparticles
Document Type
Article
Publication Date
4-1-2022
Abstract
Multipotent antioxidants (MPAO) were synthesized and characterized by FTIR, NMR. The functionalized nanoparticles (IONP@AO) were characterized by FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX. IONP@AO1 and IONP@AO2 have average particles size of 10 nm and 11 nm, respectively. The functionalized IONP@AO has a superparamagnetic nature, with saturation magnetization of 45 emu center dot g(-1). Structure-based virtual screening of the designed MPAO was performed by PASS analysis and ADMET studies to discover and predict the molecule's potential bioactivities and safety profile before the synthesis procedure. The half-maximal inhibitory concentration (IC50) of DPPH analysis results showed a four-fold decrease in radical scavenging by IONP@AO compared to IONP. In addition to antioxidant activity, IONP@AO showed suitable antimicrobial activities when tested on various bacterial and fungal strains. The advantage of the developed nanoantioxidants is that they have a strong affinity towards biomolecules such as enzymes, proteins, amino acids, and DNA. Thus, synthesized nanoantioxidants can be used to develop biomedicines that can act as antioxidant, antimicrobial, and anticancer agents.
Keywords
Multipotent antioxidants, Nanoantioxidants, Functionalization, Magnetite nanoparticles
Divisions
nanotechnology
Funders
King Khalid University,Universiti Malaya
Publication Title
Coatings
Volume
12
Issue
4
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND