Chemical constituents and anti-neuroblastoma activity from boesenbergia stenophylla
Document Type
Article
Publication Date
4-1-2022
Abstract
Three diarylheptanoids and one flavonoid, i.e. 7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (4), 5R-hydroxy-7-(4-hydroxy-3-methoxy phenyl)-1-phenylheptan-3-o ne (5), 1,7-diphenylhept-4-en-3-one (6), and 3,5,7-trihydroxyflavone (7) were isolated and characterized from the rhizome of Boesenbergia stenophylla. Compounds 2 and 4 displayed excellent anti-neuroblastoma activity which reduces the cell viability to 30% and 20%, respectively. The results from the molecular docking experiments targeting the protein kinases regulating neuroblastoma cell survival (PI3K/AKT1 signalling pathway) are consistent with that of the in vitro results. Finally, the structures of 4-7 were elucidated using spectroscopic methods (UV, IR, NMR, and HRESIMS).
Keywords
AKT1, Anti-neuroblastoma, Boesenbergia stenophylla, N2A, PI3K
Divisions
CHEMISTRY
Funders
Universiti Malaya [Grant No: GPF055B-2018; ST004-2018; ST008-2020]
Publication Title
Sains Malaysiana
Volume
51
Issue
4
Publisher
Penerbit Universiti Kebangsaan Malaysia
Publisher Location
FACULTY SCIENCE & TECHNOLOGY, BANGI, SELANGOR, 43600, MALAYSIA