Cytotoxic constituent of Melicope latifolia (DC.) T. G. Hartley
Document Type
Article
Publication Date
3-19-2022
Abstract
An undescribed conjugated sesquiterpene, amelicarin (1), together with nine known compounds (2-10) were isolated for the first time from Melicope latifolia. Their structures were elucidated by extensive NMR spectroscopic and mass spectrometric methods. The conjugated sesquiterpene possesses a unique 6/6/9/4-ring fused tetracyclic skeleton. The proposed biosynthesis pathway of 1 consist of three reactions steps: (1) polyketide formation, (2) cyclisation and (3) addition to form the conjugated sesquiterpenoid as final metabolite. Out of the ten isolated metabolites, amelicarin (1) showed activity against 4 cancerous cell lines namely SK-MEL skin cancer, KB oral cancer, BT-549 breast cancer, and SK-OV-3 ovarian cancer with IC50 values between 15 and 25 mu g/mL.
Keywords
Melicope latifolia, Rutaceae, Conjugated sesquiterpene, isolation, Cytotoxicity
Divisions
CHEMISTRY
Funders
Universiti Putra Malaysia [GP-IPS 9618900]
Publication Title
Natural Product Research
Volume
36
Issue
6
Publisher
Taylor & Francis
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND