Bio-enhanced polyrhodanine/graphene Oxide/Fe3O4 nanocomposite with kombucha solvent supernatant as ultra-sensitive biosensor for detection of doxorubicin hydrochloride in biological fluids
Document Type
Article
Publication Date
3-1-2022
Abstract
Cardiotoxicity and other side effects of current antineoplastic agents with narrow therapeutic windows, such as doxorubicin hydrochloride (DOX), have increased the need for advanced real-time monitoring approaches to control their dosage and minimize common side effects. In this study, we reinforced the biocompatible and electrosensitive polymeric structure of polyrhodanine with iron(II,III) oxide (Fe3O4) and coated graphene oxide (GO) with Fe3O4 (GO-Fe3O4) nanoparticles. The resulting hybrid polymeric platform was bio-enhanced by extraction of kombucha solvent supernatant and used as a highly sensitive biosensor with enhanced electroactive C=N+ functional groups for real-time detection of DOX in the human blood plasma sample. The developed platform was well characterized by performing different analyses, and its applicability was evaluated using an electrochemical approach. The results showed the superior sensitivity (167.62 mu A mu M-1 cm(-2)), low detection limit (DL, 0.008 mu M), and quantification limit (QL, 0.056 mu M) of the proposed biosensor. The biosensor detected DOX in the biological fluid with optimal accuracy (>99%), highlighting the ideal performance of the fabricated polymeric biosensor.
Keywords
Polyrhodanine, Graphene oxide, Kombucha solvent supernatant, Biosensor, Doxorubicin
Divisions
nanocat
Funders
None
Publication Title
Materials Chemistry and Physics
Volume
279
Publisher
Elsevier Science SA
Publisher Location
PO BOX 564, 1001 LAUSANNE, SWITZERLAND