Vaccine for diabetes-where do we stand?
Document Type
Article
Publication Date
8-1-2022
Abstract
Diabetes is an endocrinological disorder with a rapidly increasing number of patients globally. Over the last few years, the alarming status of diabetes has become a pivotal factor pertaining to morbidity and mortality among the youth as well as middle-aged people. Current developments in our understanding related to autoimmune responses leading to diabetes have developed a cause for concern in the prospective usage of immunomodulatory agents to prevent diabetes. The mechanism of action of vaccines varies greatly, such as removing autoreactive T cells and inhibiting the interactions between immune cells. Currently, most developed diabetes vaccines have been tested in animal models, while only a few human trials have been completed with positive outcomes. In this review, we investigate the undergoing clinical trial studies for the development of a prototype diabetes vaccine.
Keywords
diabetes, vaccines, clinical trials, insulin, GLP
Publication Title
International Journal of Molecular Sciences
Recommended Citation
Chellappan, Dinesh Kumar; Bhandare, Richie R.; Shaik, Afzal B.; Prasad, Krishna; Suhaimi, Nurfatihah Azlyna Ahmad; Yap, Wei Sheng; Das, Arpita; Banerjee, Pradipta; Ghosh, Nandini; Guith, Tanner; Das, Amitava; Balakrishnan, Sarannya; Candasamy, Mayuren; Mayuren, Jayashree; Palaniveloo, Kishneth; Gupta, Gaurav; Singh, Sachin Kumar; and Dua, Kamal, "Vaccine for diabetes-where do we stand?" (2022). Research Publications (2021 to 2025). 936.
https://knova.um.edu.my/research_publications_2021_2025/936
Divisions
ocean
Funders
Deanship of Graduate Studies and Research, Ajman University
Volume
23
Issue
16
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND