Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances
Document Type
Article
Publication Date
2-1-2022
Abstract
The emergence of clinical complications and therapeutic challenges for treating various diseases necessitate the discovery of novel restorative functional materials. Polymer-based drug delivery systems have been extensively reported in the last two decades. Recently, there has been an increasing interest in the progression of natural biopolymers based controlled therapeutic strategies, especially in drug delivery and tissue engineering applications. However, the solubility and functionalisation due to their complex network structure and intramolecular bonding seem challenging. This review explores the current advancement and prospects of the most promising natural polymers such as cellulose, starch and their derivatives-based drug delivery vehicles like hydrogels, films and composites, in combating major ailments such as bone infections, microbial infections, and cancers. In addition, selective drug targeting using metal-drug (MD) and MD-based polymeric missiles have been exciting but challenging for its application in cancer therapeutics. Owing to high biocompatibility of starch and cellulose, these materials have been extensively evaluated in biomedical and pharmaceutical applications. This review presents a detailed impression of the current trends for the construction of biopolymer-based tissue engineering, drug/gene/protein delivery vehicles.
Keywords
Cellulose, Starch, Cross-linking, Anticancer, Drug delivery, Antimicrobials, Wound healing
Divisions
fac_med,Science
Funders
King Saud University [Grant No: RG-1435-065]
Publication Title
Biomedicine & Pharmacotherapy
Volume
146
Publisher
Elsevier France-Editions Scientifiques Medicales Elsevier
Publisher Location
65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE