C-kit expression in oral leukoplakia
Document Type
Article
Publication Date
2-1-2022
Abstract
Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required.
Keywords
CD 117, Disease progression, Oral dysplasia, Oral leukoplakia, Risk prediction
Divisions
OralMaxillofacialSurgery
Funders
SEGi University Research Grant [SEGiuni/VC/RIMC/33/19-12-2016]
Publication Title
Journal of the College of Physicians and Surgeons Pakistan
Volume
32
Issue
2
Publisher
College of Physicians and Surgeons Pakistan
Publisher Location
SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN