Recent developments in metabolomics studies of endophytic fungi
Document Type
Article
Publication Date
1-1-2022
Abstract
Endophytic fungi are microorganisms that colonize living plants' tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the increasing trends in human health problems and diseases have escalated the search for bioactive metabolites from endophytic fungi. The conventional bioassay-guided study is known as laborious due to chemical complexity. Thus, metabolomics studies have attracted extensive research interest owing to their potential in dealing with a vast number of metabolites. Metabolomics coupled with advanced analytical tools provides a comprehensive insight into systems biology. Despite its wide scientific attention, endophytic fungi metabolomics are relatively unexploited. This review highlights the recent developments in metabolomics studies of endophytic fungi in obtaining the global metabolites picture.
Keywords
Metabolomics, Endophytic fungi, Bioactive metabolites, Nuclear magnetic resonance, Liquid chromatography-high-resolution mass spectrometry, Extraction, Analytical tool, Systems biology
Divisions
clinicalpharmacy
Funders
Ministry of Education, Malaysia [FRGS/1/2018/STG01/USM/02/3]
Publication Title
Journal of Fungi
Volume
8
Issue
1
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND