Multi-analyte detection based on integrated internal and external sensing approach
Document Type
Article
Publication Date
1-1-2022
Abstract
Highly sensitive, simple and multiplex detection capabilities are key criteria of point-of-care (POC) diagnosis in clinical samples. Here, a simple and highly sensitive multi-analyte detection technique is proposed by using photonic crystal fiber (PCF) based surface plasmon resonance (SPR) sensor that employs both internal and external sensing approaches. The proposed sensor can detect two different analytes simultaneously by the internal and external plasmonic micro-channels. The light propagation through the sensor is controlled by the scaled-down air-holes to excite the free electrons of the plasmonic metal layers. The light- guiding and sensing properties of the sensor is numerically analyzed by using the Finite Element Method (FEM). The proposed sensor shows the maximum wavelength sensitivities (WS) of 12,000 nm/refractive index unit (RIU), and 10,000 nm/RIU, for the internal and external sensing approaches, respectively, and corresponding resolution of 8.33 x 10(-6) RIU and 1.0 x 10(-5) RIU. Moreover, the hybrid sensor is applicable to detect unknown analyte refractive index ( RI) in the range of 1.33 to 1.40 which covers extensively investigating analytes such as viruses, different cancer cells, glucose, proteins and DNA/RNA. Due to high sensing performance with multi-analyte detection capability, the proposed sensor can play a significant role to detect bio targets at the POC platform.
Keywords
Photonic crystal fiber, Surface plasmon resonance, Optical fiber sensors and finite element method
Divisions
fac_eng
Funders
None
Publication Title
IEEE Transactions on Nanobioscience
Volume
21
Issue
1
Publisher
IEEE-Inst Electrical Electronics Engineers Inc
Publisher Location
445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA