A facile electrochemical sensor based on a composite of electrochemically reduced graphene oxide and a PEDOT:PSS modified glassy carbon electrode for uric acid detection
Document Type
Article
Publication Date
1-1-2022
Abstract
A glassy carbon electrode modified with electrochemically reduced graphene oxide (ErGO) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) was developed for uric acid determination with dopamine as interference in artificial saliva. The electrochemical performance of the fabricated electrode was studied using both techniques of cyclic voltammetry (CV) and differential pulse voltammetry (DPV), under optimized conditions. Using DPV, the sensor based on ErGO/PEDOT:PSS modified GCE displayed a linear relationship in the concentration ranges of 10-100 mu M for uric acid. This uric acid sensor exhibited a high sensitivity with detection limits of 1.08 mu M and quantitation limit of 3.61 mu M. This sensor also showed good reproducibility for uric acid detection in artificial saliva in 5 consecutive days of measurements. This device was successfully used to analyze uric acid in artificial saliva as well as in a human saliva sample using the standard addition method.
Keywords
Electrochemically reduced graphene oxide, PEDOT, PSS, Uric acid, Dopamine, Artificial saliva
Divisions
sch_che
Funders
Ministry of Research and Technology, National Research and Innovation Agency of Republic of Indonesia [Grant No:1927/IT3.L1/PN/2021]
Publication Title
Analytical Sciences
Volume
38
Issue
1
Publisher Location
CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND