Wall stress analysis of patient-specific left ventricular hypertrophy models
Document Type
Conference Item
Publication Date
1-1-2022
Abstract
Left ventricular hypertrophy (LVH) is a complex heart disease characterised by abnormal heart wall. A wall stress analysis may provide insight on ventricular wall mechanics, and it should be conducted with patient-specific geometry for accurate assessment. This study aims to investigate the distribution of stress on the left ventricular (LV) wall of LVH patients in diastolic filling phase using the finite element method. The patient-specific LV geometries of two LVH patients were compared with two healthy subjects. The effect of individual factors in contributing to wall stress was also studied by adapting the model settings for investigation. Our results showed that the excessive wall stress observed in LVH patients (σc: 6068±342Pa, σz: 3785±161Pa, σr: 384±649Pa ), when compared to healthy subjects (σc: 2662±82Pa, σz: 1486±239Pa, σr: 0.1±47Pa ), were mainly contributed by the elevated filling pressure. Besides, an abnormal stress variation was also observed in LVH patients, especially near the region with wall thickening and distinct local wall curvature. A high convexity area was observed to have high circumferential stress and low longitudinal stress, while the opposite was noted at the local high concavity area. These findings indicate the importance of patient-specific models in wall stress assessment of LVH patients. © 2022, Springer Nature Switzerland AG.
Keywords
Cardiology, Stress analysis, Healthy subjects, Heart disease, Heart wall, Left ventricular, Left ventricular hypertrophies, Patient specific, Stresses analysis, Ventricular walls, Wall mechanics, Wall Stress, Pathology
Divisions
biomedengine
Funders
Universiti Malaya [Grant no. GPF053B-2020],University of Nottingham Malaysia Campus
Publication Title
IFMBE Proceedings
Volume
86
Publisher
Springer Science and Business Media Deutschland GmbH
Event Title
6th Kuala Lumpur International Conference on Biomedical Engineering, BioMed 2021
Event Location
Virtual, Online
Event Dates
28-29 July 2021
Event Type
conference