Small molecules as LIM kinase inhibitors
Document Type
Article
Publication Date
1-1-2022
Abstract
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.
Keywords
Cytoskeleton, Thiazole, Thienopyridine Derivatives, Thienopyrimidine, Synthesis, LIM Kinase
Divisions
nanotechnology
Funders
Deanship of Scientific Research at Jouf University ]DSR-2021-01-0208]
Publication Title
Current Medicinal Chemistry
Volume
29
Issue
17
Publisher
Bentham Science Publ Ltd
Publisher Location
EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES