Docetaxel-induced febrile neutropenia in breast cancer patients in Malaysia
Document Type
Article
Publication Date
1-1-2022
Abstract
Docetaxel induced febrile neutropenia (FN) is a common adverse event encountered by breast cancer patients worldwide, especially among Asian patients. We aim to evaluate incidence of FN in breast cancer patients receiving docetaxel in Malaysia. We retrospectively reviewed the records from patients with breast cancer who received docetaxel in a university-hospital. The incidence of FN, length of hospital stay, incidence of ICU admission, incidence and grade of neutropenia were evaluated. Among 237 breast cancer patients, incidence of FN was 14.34 (34 patients). Mean length of hospital stay was 9.28 days (2 to 94 days). Two patients (0.84) required admission to the ICU with the length of stay being 4 and 60 days respectively. Incidences of neutropenia are 27.8 (grade 1), 0.8 (grade 2), 1.69 (grade 3) and 0.4 (grade 4). The incidence of febrile neutropenia due to docetaxel was higher among this population. This data may help to determine the optimal dose of docetaxel in breast cancer patients. © 2022, Faculty of Medicine, University of Malaya. All rights reserved.
Keywords
Docetaxel, Adult, Aged, Article, Blood cell count, Breast cancer, Breast carcinoma, Chemotherapy, Drug therapy, Febrile neutropenia, Female, Histology, Hospitalization, Human, Human tissue, Intensive care unit, Length of stay, Major clinical study, Male, Neoadjuvant therapy, Overall survival, Palliative therapy, Retrospective study
Divisions
fac_med
Publication Title
Journal of Health and Translational Medicine
Volume
25
Issue
1
Publisher
University of Malaya Medical Centre
Additional Information
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