Chemical advances in therapeutic application of exosomes and liposomes
Document Type
Article
Publication Date
1-1-2022
Abstract
Exosomes and liposomes are vesicular nanoparticles that can encapsulate functional cargo. The chemical similarities between naturally occurring exosomes and synthetic liposomes have accelerated the development of exosome mimetics as a therapeutic drug delivery platform under physiological and pathological environments. To maximise the applications of exosomes and liposomes in the clinical setting, it is essential to look into their basic chemical properties and utilise these characteristics to optimise the preparation, loading, modification and hybridisation. This review summarises the chemical and biological properties of both exosomal and liposomal systems as well as some of the challenges related to their production and application. This article concludes with a discussion on potential perspectives for the integration of exosomal and liposomal technologies in mapping better approaches for their biomedical use, especially in therapeutics.
Keywords
Exosome, Liposome, Biogenesis, Cargo, Hybridisation, Drug delivery
Divisions
fac_med,rms
Funders
Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia,FRGS/1/2019/SKK08/MAHSA/02/5
Publication Title
Current Medical Chemistry
Volume
29
Issue
25
Publisher
Bentham Science Publ Ltd
Publisher Location
EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES