Concept design of transdermal microneedles for diagnosis and drug delivery: A review
Document Type
Article
Publication Date
12-1-2021
Abstract
Microneedles (MNs) are one of intriguing approach for efficient transdermal drug delivery that penetrates the protective skin barrier in a painless and less invasive way. In recent years, multidisciplinary studies have been conducted to improve their properties to meet stringent requirements and obtain market release approval. This review aims to summarize the latest concept design with unique properties in the advancement of transdermal MNs for diagnosis and therapeutic application. Numerous significant innovation strategies in improving MNs in aspects of adhesion ability, dosing capacity, drug-controlled release, diffusion control ability, site-targeted and on-demand drug delivery, and biomarker or drug release monitoring are presented. Given that the majority of technologies used in such design are exclusively laboratory-based, striving toward commercialization is a critical aspect of the revolution. Key challenges and future perspectives in industrial and economic aspects are identified with the intention of translating the reviewed technologies into marketable products.
Keywords
Controlled release, Designs, Diagnosis, Drug delivery, Microneedles, Responsive, Transdermal
Divisions
fac_eng
Funders
"Skim Latihan Akademik Muda" (SLAM) from Universiti Teknologi Malaysia (UTM),Impact-Oriented Interdisciplinary Research Grant Programme from Universiti Malaya (UM) [IIRG018B-2019]
Publication Title
Advanced Engineering Materials
Volume
23
Issue
12
Publisher
Wiley-V C H Verlag GMBH
Publisher Location
POSTFACH 101161, 69451 WEINHEIM, GERMANY