L-cysteine capped silver nanoparticles as chiral recognition sensor for ketoprofen enantiomers
Document Type
Article
Publication Date
11-1-2021
Abstract
A simple, inexpensive but effective approach for visual chiral recognition of ketoprofen enantiomers was developed using L-cysteine capped silver nanoparticles (L-Cys-AgNPs) as a colorimetric sensor. Upon the addition of R-ketoprofen to L-Cys-AgNPs, rapid aggregation occurred, and the solution changed color from yellow to green. However, the presence of S-ketoprofen did not induce any color change. The results were characterized using UV-Vis, FESEM, FT-IR, SERS, and zeta potential measurements. The chiral assay described in this work is easily distinguished with the naked eyes or using a UV-Vis spectrometer. The sensor revealed a good linear response to ketoprofen enantiomers in the concentration range of 8.33-33.3 mu M with a detection limit of 4.52 mu M and relative standard deviation of 3.73%. The proposed method was utilized for the determination of ketoprofen racemic mixtures in water samples and commercial tablets. The method excels by its simplicity, low cost, and good availability of materials.
Keywords
Chiral recognition, Colorimetric sensor, Ketoprofen enantiomers, L-cysteine, Silver nanoparticles
Divisions
CHEMISTRY
Publication Title
Chirality
Volume
33
Issue
11
Publisher
Wiley
Publisher Location
111 RIVER ST, HOBOKEN 07030-5774, NJ USA