Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease

Document Type

Article

Publication Date

7-28-2022

Abstract

Alzheimer's disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (A beta) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of A beta plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High A beta plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of A beta plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of A beta plaques were located in the amygdala, and the cerebellum; but no A beta plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of A beta plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of A beta deposition in the brain and its inter-regional correlation. This suggests an association between A beta plaque deposition and specific brain regions in AD pathogenesis.

Keywords

Alzheimer's disease, Amyloid-beta (AB), Morphology, Neuroanatomy, 5xFAD, Dementia

Publication Title

Frontiers in Aging Neuroscience

Divisions

fac_med

Funders

None

Volume

14

Publisher

Frontiers Media SA

Publisher Location

AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND

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