A review of commercial developments and recent laboratory research of dialyzers and membranes for hemodialysis application
Document Type
Article
Publication Date
10-1-2021
Abstract
Dialyzers have been commercially used for hemodialysis application since the 1950s, but progress in improving their efficiencies has never stopped over the decades. This article aims to provide an up-to-date review on the commercial developments and recent laboratory research of dialyzers for hemodialysis application and to discuss the technical aspects of dialyzer development, including hollow fiber membrane materials, dialyzer design, sterilization processes and flow simulation. The technical challenges of dialyzers are also highlighted in this review, which discusses the research areas that need to be prioritized to further improve the properties of dialyzers, such as flux, biocompatibility, flow distribution and urea clearance rate. We hope this review article can provide insights to researchers in developing/designing an ideal dialyzer that can bring the best hemodialysis treatment outcomes to kidney disease patients.
Keywords
Commercial dialyzer, Dialysis, Membrane, Dialyzer design, Hemodialysis, blood
Divisions
medicinedept
Funders
PETRONAS through YUTP grant [015LC0-169],Universiti Teknologi Malaysia through UTM SGSHINE [Q.J130000.2451.07G79],Ministry of Higher Education, Malaysia, under Prototype Research Grant Scheme (PRGS) [R.J130000.7809.4L704],Universiti Teknologi Malaysia under the Post-Doctoral Fellowship Scheme
Publication Title
Membranes
Volume
11
Issue
10
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND