Oxidative degradation of acetaminophen using superoxide ion generated in ionic liquid/aprotic solvent binary system
Document Type
Article
Publication Date
9-1-2021
Abstract
The environmental contamination by pharmaceuticals is on a continual rise, ensuing levels which are imminent globally. While the alleged harmful effects of drug waste are being rapidly substantiated at present, the development of effective and `greener' techniques to degrade pharmaceuticals is a new challenge. This study explores a method using superoxide ion (O2 center dot- ) as an oxidant for degradation of acetaminophen (ACTM) as a prototype of active pharmaceutical ingredients (APIs). The binary system consisting of bis(trifluoromethylsulfonyl)imide TFSI-] anion-based hydrophobic ionic liquids (ILs) and acetonitrile (AcN) as an aprotic solvent were used in varied combinations to generate O2 center dot- for subsequent in situ degradation of ACTM. The O2 center dot- was chemically generated by dissolution of potassium superoxide (KO2) in BTEAmm+]TFSI- ]/AcN and EMIm+]TFSI- ]/AcN systems to achieve a complete degradation of the drug. A characteristic peak at the wavelength of 258 nm in UV-Visible spectrophotometry was indicative of the stable generation of O2 center dot- species, which confirms its presence in certain reaction media used. Cyclic voltammetry (CV) was used in order to further validate O2 center dot- as a major reactive oxygen species generated in selected aprotic media, as evidently indicated by the oxygen reduction peak in the cyclic voltammograms. In BTEAmm+]TFSI- ]/AcN, more than 98% of ACTM was eliminated within 2 h. The ILs were recycled and further employed for up to 5 replica cycles of degradation, depicting high efficacy of the environmentally benign regenerated media. Moreover, evaluation of TOC decay determined that complete mineralization of ACTM was achieved under optimum conditions. A degradation pathway was proposed based on the identification of intermediate transformation products resulting from ACTM oxidation by means of LCMS. This work will serve to instigate further progression in the direct use of O2 center dot- as a suitable alternative approach for environmental remediation appertaining to pharmaceutical contaminants.
Keywords
Pharmaceutical waste, Hazardous material, Green solvent, Reactive oxygen species, Advanced oxidation process, Paracetamol
Divisions
CHEMISTRY
Funders
Fundamental Research Grant Scheme (FP071-2018A),University Malaya Centre for Ionic Liquids (UMCiL)
Publication Title
Separation and Purification Technology
Volume
270
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS