Cellulose supported magnetic nanohybrids: Synthesis, physicomagnetic properties and biomedical applications-a review
Document Type
Article
Publication Date
9-1-2021
Abstract
Cellulose and its forms are widely used in biomedical applications due to their biocompatibility, biodegradability and lack of cytotoxicity. It provides ample opportunities for the functionalization of supported magnetic nanohybrids (CSMNs). Because of the abundance of surface hydroxyl groups, they are surface tunable in either homogeneous or heterogeneous solvents and thus act as a substrate or template for the CSMNs' development. The present review emphasizes on the synthesis of various CSMNs, their physicomagnetic properties, and potential applications such as stimuli-responsive drug delivery systems, MRI, enzyme encapsulation, nucleic acid extraction, wound healing and tissue engineering. The impact of CSMNs on cytotoxicity, magnetic hyperthermia, and folate-conjugates is highlighted in particular, based on their structures, cell viability, and stability. Finally, the review also discussed the challenges and prospects of CSMNs' development. This review is expected to provide CSMNs' development roadmap in the context of 21st-century demands for biomedical therapeutics.
Keywords
Magneto-responsive cellulose, Cancer therapy, Drug delivery, MRI, Enzyme immobilization, Folate-conjugate
Divisions
fac_eng
Funders
Faculty of Engineering, University of Malaya[H-16001-D00048],Faculty of Engineering, University of Malaya[GPF077A-2018],Faculty of Engineering, University of Malaya[IIRG001-2020IISS]
Publication Title
Carbohydrate Polymers
Volume
267
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND