Mechanisms linking vitamin D deficiency to impaired metabolism: An overview
Document Type
Article
Publication Date
7-6-2022
Abstract
Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic beta-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.
Keywords
Inhibits oxidative stress, Serum 25-hydroxyvitamin D, Polycystic-ovary-syndrome, Insulin-receptor gene, Beta-cell mass, D supplementation, 1, 25-dihydroxyvitamin D-3, Intracellular calcium, Glucose-metabolism, Double-blind
Divisions
physiodept
Funders
Universiti Malaya (Grant No: PV038-2019)
Publication Title
International Journal of Endocrinology
Volume
2022
Publisher
Hindawi Publishing Corporation
Publisher Location
ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND