Monomeric, dimeric, and trimeric tropane alkaloids from pellacalyx saccardianus
Document Type
Article
Publication Date
8-27-2021
Abstract
Seven new tropane alkaloids, including five monomeric (1-5), one dimeric (6), and one trimeric (7) 3 alpha-nortropane ester, along with two known monomeric nortropane alkaloids (8 and 9), were isolated from the leaves and bark of Pellacalyx saccardianus. Their structures, including the absolute configuration of the enantiomeric pair of (+/-)-6, were elucidated by comprehensive spectroscopic analyses. Alkaloids 6 and 7 showed cytotoxicity toward human pancreatic cancer cell lines (AsPC-1, BxPC3, PANC-1, and SW1990). Alkaloids 1, 4, and 9 induced a smooth muscle relaxation effect comparable to that of atropine (E-max 106.1 +/- 7.5%, 97.0 +/- 5.2%, 100.9 +/- 1.4%, 111.7 +/- 1.7%, respectively) on isolated rat tracheal rings.
Keywords
Atropine analog, Serythroxylum, Spectroscopy, Leaves, Series, Amines, Plants
Divisions
fac_med
Publication Title
Journal of Natural Products
Volume
84
Issue
8
Publisher
American Chemical Society
Publisher Location
1155 16TH ST, NW, WASHINGTON, DC 20036 USA