Synthesis, antiproliferative and antimalarial activities of dinuclear silver(I) complexes with triphenylphosphine and rhiosemicarbazones ligands

Document Type

Article

Publication Date

8-1-2021

Abstract

A series of six sulfur-bridged Binuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as H-1, C-13, P-31{H-1}s, COSY, and H-1-C-13 nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.

Keywords

Thiosemicarbazone, Silver complexes, Antiplasmodial, Antiproliferative, Phosphine

Publication Title

Indonesian Journal of Chemistry

Divisions

Science

Funders

Geran Penyelidikan Universiti Malaya (UMRG) -AFR Frontier Science [RG357-15AFR] FR,University of Malaya IPPP Grant[PG002-2015A]

Volume

21

Issue

3

Publisher

Universitas Gadjah Mada

This document is currently not available here.

Share

COinS