Nutritional profile, antioxidative and antihyperglycemic properties of padina tetrastromatica from Tioman Island, Malaysia
Document Type
Article
Publication Date
8-1-2021
Abstract
Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. Padina tetrastromatica is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of P. tetrastromatica extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg(-1) body weight of streptozotocin. Oral treatment with 200 and 400 mg kg(-1) of P. tetrastromatica ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with P. tetrastromatica extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, P. tetrastromatica extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of P. tetrastromatica at 400 mg kg(-1) dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of P. tetrastromatica.
Keywords
Seaweed, Brown algae, Padina tetrastromatica, Tioman Island, Functional food, Nutrition, Antioxidant, Antidiabetic, Antihyperglycemic
Divisions
ocean
Funders
International Medical University[BP1-01/2018(45)],Science and Technology Research Partnership for Sustainable Development (SATREPS) Program entitled 'Development of Advanced Hybrid Ocean Thermal Energy Conversion (OTEC) Technology for Low Carbon Society and Sustainable Energy System: First Experimental O,Japan International Cooperation Agency (JICA),Ministry of Education, Malaysia,UTM Ocean Thermal Energy Centre (UTM OTEC), Universiti Teknologi Malaysia (UTM)[R.K130000.7809.4L887],UTM Ocean Thermal Energy Centre (UTM OTEC), Universiti Teknologi Malaysia (UTM)[IF045-2019]
Publication Title
Foods
Volume
10
Issue
8
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND