Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)

Document Type

Article

Publication Date

3-1-2025

Abstract

Colorectal cancer (CRC), an emerging public health concern, is one of the leading causes of cancer morbidity and mortality worldwide. An increasing body of evidence shows that dysfunction in metabolic reprogramming is a crucial characteristic of CRC progression. Specifically, metabolic reprogramming abnormalities in glucose, glutamine and lipid metabolism provide the tumour with energy and nutrients to support its rapid cell proliferation and survival. More recently, microRNAs (miRNAs) appear to be involved in the pathogenesis of CRC, including regulatory roles in energy metabolism. In addition, it has been revealed that dysbiosis in CRC might play a key role in impairing the host metabolic reprogramming processes, and while the exact interactions remain unclear, the link may lie with miRNAs. Hence, the aims of the current review include first, to delineate the metabolic reprogramming abnormalities in CRC; second, to explain how miRNAs mediate the aberrant regulations of CRC metabolic pathways; third, linking miRNAs with metabolic abnormalities and dysbiosis in CRC and finally, to discuss the roles of miRNAs as potential biomarkers.

Keywords

microRNA, Metabolic reprogramming, Colorectal cancer, Glucose metabolism, Lipid metabolism, Glutamine metabolism, Gut microbiota, Microbiome

Publication Title

International Journal of Molecular Medicine

Divisions

sch_med

Funders

Ministry of Higher Education, Malaysia [Grant no. LR001B‑2019]

Volume

55

Issue

3

Publisher

Elsevier

Publisher Location

POB 18179, ATHENS, 116 10, GREECE

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