Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review
Document Type
Article
Publication Date
3-1-2025
Abstract
Recent advancements in nanotechnology have significantly contributed to developing innovative approaches in cancer therapy, particularly for oral cancer. This review focuses on the promising strategy of using greensynthesized metallic nanoparticles, which possess unique physicochemical properties suitable for targeted drug delivery and enhanced cytotoxicity against cancer cells. These Nanoparticles (NPs) are synthesized through environmentally friendly methods that utilize natural extracts or biomolecules as reducing and stabilizing agents. Their biocompatibility and capacity to penetrate biological barriers make them excellent for delivering therapeutic drugs directly to oral cancer cells, reducing systemic toxicity and increasing the efficacy of therapy. Numerous research on the cytotoxic effects of plant-synthesized Metallic Nanoparticles (MNPs) on oral cancer have demonstrated significant anticancer properties, attributable to their minute size and elevated surface-tovolume ratio. Functionalizing these nanoparticles with targeted ligands, such as peptides or antibodies allows for specific detection and binding to receptors that are overexpressed on cancer cell surfaces. This specific method improves cellular uptake of therapeutic medicines, resulting in enhanced apoptosis and suppression of tumor cell proliferation. Additionally, the tunability of the physicochemical properties of these nanoparticles allows for optimization of their therapeutic efficacy and pharmacokinetics. Overall, this review highlights that green-synthesized metallic nanoparticles can be used to develop targeted and successful diagnosis of the oral cancer treatment.
Keywords
Oral cancer, Metallic Nanoparticles, Plant extract, Bioactive compounds, Drug delivery
Divisions
nanotechnology
Publication Title
Inorganic Chemistry Communications
Volume
173
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS