Hydrazide-Hydrazone derivatives and their antitubercular activity

Authors

• B. R. Thorat
• S. N. Mali
• Umang Shah
• A. Garg
• R. Agrawal
• S. A. Arvindekar
• J. N. Cruz
• M. Santana de Oliveira
• A. B. Shaik
• B. V. S. Lokesh

Document Type

Article

Publication Date

2-1-2025

Abstract

This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R-1-HN-N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones' role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.

Keywords

Tuberculosis, Hydrazide-hydrazones, Mycobacterium tuberculosis resistance

Publication Title

Russian Journal of Bioorganic Chemistry

Recommended Citation

Thorat, B. R.; Mali, S. N.; Shah, Umang; Garg, A.; Agrawal, R.; Arvindekar, S. A.; Cruz, J. N.; de Oliveira, M. Santana; Shaik, A. B.; and Lokesh, B. V. S., "Hydrazide-Hydrazone derivatives and their antitubercular activity" (2025). Research Publications (2021 to 2025). 6383.
https://knova.um.edu.my/research_publications_2021_2025/6383

Divisions

pharmacy

Volume

51

Issue

1

Publisher

Maik Nauka/Interperiodica/Springer

Publisher Location

233 SPRING ST, NEW YORK, NY 10013-1578 USA