Hydrazide-Hydrazone derivatives and their antitubercular activity
Document Type
Article
Publication Date
2-1-2025
Abstract
This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R-1-HN-N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones' role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.
Keywords
Tuberculosis, Hydrazide-hydrazones, Mycobacterium tuberculosis resistance
Divisions
pharmacy
Publication Title
Russian Journal of Bioorganic Chemistry
Volume
51
Issue
1
Publisher
Maik Nauka/Interperiodica/Springer
Publisher Location
233 SPRING ST, NEW YORK, NY 10013-1578 USA