Hydrazide-Hydrazone derivatives and their antitubercular activity
Document Type
Article
Publication Date
2-1-2025
Abstract
This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R-1-HN-N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones' role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.
Keywords
Tuberculosis, Hydrazide-hydrazones, Mycobacterium tuberculosis resistance
Publication Title
Russian Journal of Bioorganic Chemistry
DOI
10.1134/S1068162025010054
Recommended Citation
Thorat, B. R.; Mali, S. N.; Shah, Umang; Garg, A.; Agrawal, R.; Arvindekar, S. A.; Cruz, J. N.; de Oliveira, M. Santana; Shaik, A. B.; and Lokesh, B. V. S., "Hydrazide-Hydrazone derivatives and their antitubercular activity" (2025). Research Publications (2021 to 2025). 6383.
https://knova.um.edu.my/research_publications_2021_2025/6383
Volume
51
Issue
1
First Page
35
Last Page
52
Publisher
Maik Nauka/Interperiodica/Springer