Novel Isoxazole Functionalized Quinazolinone Derivatives and Their Anticancer Activity

Authors

• S. K. Konda
• A. K. Kanuri, Universiti Malaya
• B. K. Chennuri
• R. Anjum
• R. Trivedi
• M. Patlola
• S. Yamini
• S. Bhoomandla

Document Type

Article

Publication Date

1-1-2025

Abstract

AbstractA series of novel isoxazole functionalized quinazolinone derivatives was prepared by hydrolysis of 2-amino-6-(trifluoromethyl)benzonitrile to 2-amino-6-(trifluoromethyl)benzoic acid, followed by the reaction with phenyl isothiocyanate to get 2-mercapto-3-phenyl-5-(trifluoromethyl)quinazolin-4(3H)-one, which was further alkylated with propargyl bromide to obtain propargylated quinazolinone derivatives. Terminal propargyl group was reacted with various substituted benzaldehyde oximes in the presence of strong base to get isoxazole substituted quinazolinone derivatives. All the final compounds evaluated for anticancer activity against four human cancer cell lines such as HeLa, COLO 205, HepG2, MCF7 and promising compounds were revealed.

Keywords

quinazolinone, propargylation, isoxazole, anticancer activity

Publication Title

Russian Journal of General Chemistry

DOI

10.1134/S1070363224611128

Recommended Citation

Konda, S. K.; Kanuri, A. K.; Chennuri, B. K.; Anjum, R.; Trivedi, R.; Patlola, M.; Yamini, S.; and Bhoomandla, S., "Novel Isoxazole Functionalized Quinazolinone Derivatives and Their Anticancer Activity" (2025). Research Publications (2021 to 2025). 6269.
https://knova.um.edu.my/research_publications_2021_2025/6269

Volume

95

Issue

1

First Page

146

Last Page

154

Publisher

Springer