Novel Isoxazole Functionalized Quinazolinone Derivatives and Their Anticancer Activity
Document Type
Article
Publication Date
1-1-2025
Abstract
AbstractA series of novel isoxazole functionalized quinazolinone derivatives was prepared by hydrolysis of 2-amino-6-(trifluoromethyl)benzonitrile to 2-amino-6-(trifluoromethyl)benzoic acid, followed by the reaction with phenyl isothiocyanate to get 2-mercapto-3-phenyl-5-(trifluoromethyl)quinazolin-4(3H)-one, which was further alkylated with propargyl bromide to obtain propargylated quinazolinone derivatives. Terminal propargyl group was reacted with various substituted benzaldehyde oximes in the presence of strong base to get isoxazole substituted quinazolinone derivatives. All the final compounds evaluated for anticancer activity against four human cancer cell lines such as HeLa, COLO 205, HepG2, MCF7 and promising compounds were revealed.
Keywords
quinazolinone, propargylation, isoxazole, anticancer activity
Divisions
phartech
Publication Title
Russian Journal of General Chemistry
Volume
95
Issue
1
Publisher
Springer
Publisher Location
233 SPRING ST, NEW YORK, NY 10013-1578 USA