Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk
Document Type
Article
Publication Date
10-1-2024
Abstract
Decades ago, Neel's Thrifty Genotype Hypothesis posited that human evolutionary history and environmental change interact to influence cardiometabolic health. We discuss the history, evidence, and modern day interpretation of this idea. We also provide possible study designs for empirical tests, focusing on working with subsistence-level groups undergoing lifestyle transitions.
Keywords
Thrifty Genotype Hypothesis, Evolutionary Mismatch Hypothesis, genotype x environment interactions, Orang Asli
Divisions
medicinedept,Parasit
Funders
Orang Asli Health and Lifeways Project,Center for Orang Asli Concerns,Malaysian Red Crescent Society,Federation of Private Medical Practitioners' Associations of Malaysia,Hospital Orang Asli Gombak,Universiti Malaya
Publication Title
Evolution, Medicine, and Public Health
Volume
12
Issue
1
Publisher
Oxford University Press
Publisher Location
GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND