Carboxymethyl cellulose hydrogel for pH-responsive drug release of curcumin
Document Type
Article
Publication Date
10-1-2024
Abstract
This study outlines the development of a pH-sensitive hydrogel for hydrophobic drug delivery by cross-linking carboxymethyl cellulose (CMC) with varying fumaric acid (FA) concentrations (9%-26%). FTIR analysis of CMC-FA-26% hydrogel showed a prominent band at 1714 cm-1, indicating the formation of ester bond. Compression tests demonstrated increased strength with cross-linking density changing from 9 to 26%. Stress-strain analysis revealed plastic deformation beyond 80% strain, with compression stress rising from 0.12 +/- 0.1 to 1.9 +/- 0.1 MPa as FA content increased from 9 to 26%. Thermogravimetric analysis revealed higher weight reduction (25-28%) for CMC-FA-26% compared to CMC-FA-9% (16-18%) during the fumaric acid weight loss stage. Scanning electron microscopic (SEM) examination showed that the hydrogels had a porous structure, crucial for their swelling, drug loading, and release. According to the swelling results, swellability was decreased by increasing cross-linking degree, and increased by increasing pH values. In the biodegradability test, the CMC-FA-26% hydrogel showed 35% weight loss after 28 days, while the CMC-FA-9% hydrogel exhibited a 54% weight loss. To improve the compatibility between hydrophilic CMC and hydrophobic curcumin (CUR)/beta-cyclodextrin (beta-CD) was incorporated to the hydrogel. The solubility results showed that with varying the molar ratio of CUR:beta-CD from 1:1 to 1:3, the mean UV-Vis absorption changed from 0.005 to 1.048. The variation of the medium's pH from 1.2 to 12 resulted in a notable increase in the cumulative curcumin release, ranging from 5.91 to 46.63%. Drug delivery results indicated excellent drug release in alkaline medium, highlighting the hydrogel's potential for targeted drug delivery of hydrophobic drugs in the gastrointestinal tract.
Keywords
Carboxymethyl cellulose, Fumaric acid, Controlled drug delivery, Hydrophobic drug, pH sensitivity
Divisions
sch_che,cebar
Funders
Department of Polymer Science, Faculty of Applied Science, University of Sri Jayewardenepura
Publication Title
Iranian Polymer Journal
Volume
33
Issue
10
Publisher
Springer Verlag (Germany)
Publisher Location
ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES