An efficient piperazine-based tertiary poly(amic acid) heterogeneous catalyst to prepare pyrrolidinone scaffolds
Document Type
Article
Publication Date
10-1-2024
Abstract
Given the abundance of functional groups, meso- and macro-pores, and a high surface area, the piperazine-based poly(amic acid) was employed as a heterogeneous catalyst in the multicomponent reaction to prepare pyrrolidinone scaffolds in a green solvent, acting as a medium for mass transfer and crystallization solvent. The important parameters of the reaction were investigated to find the optimal reaction conditions. A conversion of 100% was obtained at reflux conditions within 30-100 min using a catalytic amount of 200 mg of piperazine-based poly(amic acid) per 2 mmol of reactants (100 mg of cat./1 mmol of reactant). The piperazine-based poly(amic acid) exhibited high recyclability and the recovered catalyst could be used in successive runs without worthy loss in its activity. This work revealed the catalytic activity of the piperazine-based poly(amic acid) as a promising functional polymeric heterogeneous catalyst for organic synthesis.
Keywords
Functional polymer, Heterogeneous catalysis, Hydrogen bond, Heterocycles, Multicomponent reaction
Divisions
nanotechnology
Funders
Nippon Sheet Glass Foundation for Materials Science and Engineering, Japan [Grant no. IF008-2023]
Publication Title
Synthetic Communications
Volume
54
Issue
19
Publisher
Taylor & Francis Ltd
Publisher Location
530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA