Application of 3D-printed bioinks in chronic wound healing: A scoping review
Document Type
Article
Publication Date
9-1-2024
Abstract
Chronic wounds, such as diabetic foot ulcers, pressure ulcers, and venous ulcers, pose significant clinical challenges and burden healthcare systems worldwide. The advent of 3D bioprinting technologies offers innovative solutions for enhancing chronic wound care. This scoping review evaluates the applications, methodologies, and effectiveness of 3D-printed bioinks in chronic wound healing, focusing on bioinks incorporating living cells to facilitate wound closure and tissue regeneration. Relevant studies were identified through comprehensive searches in databases, including PubMed, Scopus, and Web of Science databases, following strict inclusion criteria. These studies employ various 3D bioprinting techniques, predominantly extrusion-based, to create bioinks from natural or synthetic polymers. These bioinks are designed to support cell viability, promote angiogenesis, and provide structural integrity to the wound site. Despite these promising results, further research is necessary to optimize bioink formulations and printing parameters for clinical application. Overall, 3D-printed bioinks offer a transformative approach to chronic wound care, providing tailored and efficient solutions. Continued development and refinement of these technologies hold significant promise for improving chronic wound management and patient outcomes.
Keywords
Chronic wound healing, 3D printing, Bioink, Cell-laden, Regenerative medicine
Divisions
fac_med
Funders
Universiti Kebangsaan Malaysia [Grant No: DIP-2023-018],Universiti Kebangsaan Malaysia under Dana Impak Perdana 2.0 (DIP 2.0)
Publication Title
Polymers
Volume
16
Issue
17
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND