Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum
Document Type
Article
Publication Date
8-1-2024
Abstract
Alliaceumolide A ( 1 ), a new macrolide together with known ivorenolide B ( 2 ) were isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds 1 and 2 were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.
Keywords
Dysoxylum alliaceum, Meliaceae, Alliaceumolide A, Macrolide, Cytotoxic
Divisions
CHEMISTRY
Funders
Universitas Padjadjaran (1630/UN6.3.1/PT.00/2024)
Publication Title
Phytochemistry Letters
Volume
62
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS