Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum

Authors

• Sandra Amalia Riyadi
• Al Arofatus Naini
• Tri Mayanti
• Kindi Farabi
• Desi Harneti
• - Nurlelasari
• Rani Maharani
• Ronny Lesmana
• Sofa Fajriah
• Siriporn Jungsuttiwong
• Khalijah AwangFollow
• Mohamad Nurul Azmi
• Unang Supratman

Document Type

Article

Publication Date

8-1-2024

Abstract

Alliaceumolide A ( 1 ), a new macrolide together with known ivorenolide B ( 2 ) were isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds 1 and 2 were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.

Keywords

Dysoxylum alliaceum, Meliaceae, Alliaceumolide A, Macrolide, Cytotoxic

Publication Title

Phytochemistry Letters

Recommended Citation

Riyadi, Sandra Amalia; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Harneti, Desi; Nurlelasari, -; Maharani, Rani; Lesmana, Ronny; Fajriah, Sofa; Jungsuttiwong, Siriporn; Awang, Khalijah; Azmi, Mohamad Nurul; and Supratman, Unang, "Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum" (2024). Research Publications (2021 to 2025). 5450.
https://knova.um.edu.my/research_publications_2021_2025/5450

Divisions

CHEMISTRY

Funders

Universitas Padjadjaran (1630/UN6.3.1/PT.00/2024)

Volume

62

Publisher

Elsevier

Publisher Location

RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS