Skin lightening properties of zerumbone cream: A placebo-controlled study
Document Type
Article
Publication Date
6-1-2024
Abstract
Objective: Despite the demonstrated anti-melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single-blind approach. Methods: Twenty-six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18. Results: Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well-received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p < 0.05) after 1 week compared to the initial baseline. Furthermore, after 2 weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (p < 0.05). No adverse effects were observed in the group using ZER cream. Conclusion: ZER demonstrated significant potential as a skin-lightening agent.
Keywords
cream, formulation, skin lightening, zerumbone
Divisions
fac_med
Funders
Taylor's University (FRGS/1/2019/SKK02/TAYLOR/03/2); (FRGS/1/2021/SKK0/MUSM/03/4),Taylor's University - Ministry of Higher Education (MOE) under Fundamental Research Grant Project,Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians
Publication Title
Journal of Cosmetic Dermatology
Volume
23
Issue
6
Publisher
Wiley
Publisher Location
111 RIVER ST, HOBOKEN 07030-5774, NJ USA