Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities
Document Type
Article
Publication Date
6-1-2024
Abstract
Phytochemical study of the fruits of Chisocheton erythrocarpus (Hiern) allowed the identification of eight undescribed limonoids, namely erythrocarpines O - V ( 1 - 6 , 7a and 7b ), along with seven known compounds. The structures of these compounds were elucidated based on spectroscopic and HRMS data, along with electronic circular dichroism to configure the absolute configuration. Erythrocarpines O and P are gamma -hydroxybutenolide analogs of mexicanolide-type limonoids while erythrocarpine Q - V are phragmalin-type limonoids possessing a 1,29-oxymethylene bridge with either benzoyl or cinnamoyl moiety in their structures. Mosquito larvicidal activity revealed that crude DCM extract of C. erythrocarpus possessed a good larvicidal effect against Aedes aegypti larvae in 48 h (LC 50 = 153.0 ppm). Subsequent larvicidal activity of isolated compounds indicated that erythrocarpine G ( 10 ) and 14-deoxyxyloccensin K ( 11 ) were responsible for the enhanced larvicidal effect of the extract, reporting LC 50 values of 18.55 ppm and 41.16 ppm, respectively. Moreover, residual activity testing of the crude DCM extract revealed that the duration of its larvicidal effects is up to 14 days, where it maintained a 98 % larval mortality throughout the test period, under laboratory conditions.
Keywords
Chisocheton erythrocarpus, Meliaceae, Limonoids, Larvicidal activity
Divisions
CHEMISTRY,cenar
Funders
Prototype Research Grant Scheme (PRGS),Ministry of Education, Malaysia (PR002-2019A)
Publication Title
Phytochemistry
Volume
222
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND