Determining the pKa1 and pKa2 Values of 4,4′-Trimethylenedipiperidine (TMDP), a Diprotic Organic Base with Unknown pKa Values
Document Type
Article
Publication Date
6-1-2024
Abstract
The negative logarithm of the acid dissociation constant values (pK(a1) and pK(a2)) of 4,4 `-trimethylenedipiperidine (TMDP) was determined by a pH metric titration at 298 K. The experimentally determined pK(a) values were compared with the predicted pK(a) values by chem-bioinformatics software like ACD/Labs and ChemAxon. This experiment gave an excellent opportunity to deepen engagement with the Henderson-Hasselbalch equation, acid/base dissociation constant (K-a/K-b), and half equivalence point.
Keywords
4, 4'-Trimethylenedipiperidine (TMDP), Weak diprotic organic base, Dissociation constants, Half equivalent point
Divisions
nanotechnology
Funders
Ministry of Education, Malaysia,Universiti Malaya
Publication Title
Journal of Solution Chemistry
Volume
53
Issue
6
Publisher
Springer
Publisher Location
233 SPRING ST, NEW YORK, NY 10013 USA