Determining the pKa1 and pKa2 Values of 4,4′-Trimethylenedipiperidine (TMDP), a Diprotic Organic Base with Unknown pKa Values
Document Type
Article
Publication Date
6-1-2024
Abstract
The negative logarithm of the acid dissociation constant values (pK(a1) and pK(a2)) of 4,4 `-trimethylenedipiperidine (TMDP) was determined by a pH metric titration at 298 K. The experimentally determined pK(a) values were compared with the predicted pK(a) values by chem-bioinformatics software like ACD/Labs and ChemAxon. This experiment gave an excellent opportunity to deepen engagement with the Henderson-Hasselbalch equation, acid/base dissociation constant (K-a/K-b), and half equivalence point.
Keywords
4, 4'-Trimethylenedipiperidine (TMDP), Weak diprotic organic base, Dissociation constants, Half equivalent point
Publication Title
Journal of Solution Chemistry
Recommended Citation
Zaharani, Lia and Khaligh, Nader Ghaffari, "Determining the pKa1 and pKa2 Values of 4,4′-Trimethylenedipiperidine (TMDP), a Diprotic Organic Base with Unknown pKa Values" (2024). Research Publications (2021 to 2025). 5217.
https://knova.um.edu.my/research_publications_2021_2025/5217
Divisions
nanotechnology
Funders
Ministry of Education, Malaysia,Universiti Malaya
Volume
53
Issue
6
Publisher
Springer
Publisher Location
233 SPRING ST, NEW YORK, NY 10013 USA