Midface hypoplasia in syndromic craniosynostosis: predicting craniofacial growth via a novel regression model from anatomical morphometric analysis
Document Type
Article
Publication Date
4-1-2024
Abstract
Midface hypoplasia in syndromic craniosynostosis (SC) may lead to serious respiratory issues. The aim of this study was to analyse the morphometric correlation between midface and cranial base parameters in paediatric SC patients in order to formulate predictive regression models. The computed tomography scans of 18 SC patients and 20 control were imported into Materialise Mimics Medical version 21.0 software for the measurement of multiple craniofacial landmarks and correlation analysis. The results showed a strong correlation of anterior cranial base (SN), posterior cranial base (SBa), and total cranial base (NBa) (r = 0.935) to maxilla length and width (ZMR-ZML) (r = 0.864). The model of NBa = - 1.554 + 1.021(SN) + 0.753(SBa) with R2 = 0.875 is proposed to demonstrate the development of the cranial base that causes a certain degree of midface hypoplasia in SC patients. The formula is supported using a prediction model of ZMR-ZML = 5.762 + 0.920(NBa), with R2 = 0.746. The mean absolute difference and standard deviation between the predicted and true NBa and ZMR-ZML were 2.08 +/- 1.50 mm and 3.11 +/- 2.32 mm, respectively. The skeletal growth estimation models provide valuable foundation for further analysis and potential clinical application.
Keywords
Craniosynostosis, Facial bones, Craniofacial abnormalities, Cephalometry, Cranial base, Statistical model
Divisions
mathematics,oralmax
Funders
Technology Development Fund 1 (TED1) from the Ministry of Science, Technology and Innovation Malaysia (TDF08211448)
Publication Title
International Journal of Oral and Maxillofacial Surgery
Volume
53
Issue
4
Publisher
Elsevier
Publisher Location
JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND