Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review
Document Type
Article
Publication Date
4-1-2024
Abstract
This scoping review explores the impact of genetic polymorphisms on the pharmacokinetics and treatment responses of mycophenolic acid (MPA), an immunosuppressant. The study includes 83 articles from 1226 original studies, focusing on transplantation (n = 80) and autoimmune disorders (n = 3). Genetic variants in uridine 5 `-diphospho-glucuronosyltransferase (UGT1A9, UGT1A8 and UGT2B7) and transmembrane transporters (ABCC2, SLCO1B1, SLCO1B3 and ABCB1) significantly affected MPA's pharmacokinetics and susceptibility to its adverse effect. Whereas variants in several genes including UGT1A9, UGT2B7, IMPDH1 and IMPDH2 have been associated with a higher risk of transplant rejection. However, there is a lack of studies on MPA's impact on autoimmune disorders and limited research on the Asian population. The findings underscore the need for further research on MPA's impact across different populations and diseases, particularly among other Asian ethnic groups, to advance personalized medicine in MPA therapy.
Keywords
immunosuppressant, mycophenolic acid, pharmacogenomics, polymorphisms
Divisions
fac_med,pharlife,phartech
Funders
SATU Joint Research Scheme Program Universiti Malaya International Collaboration Grant,Universiti of Malaya, Malaysia and Universitas Gadjah Mada, Indonesia
Publication Title
Pharmacogenomics
Volume
25
Issue
5-6
Publisher
Taylor & Francis
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND