Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Document Type

Article

Publication Date

4-1-2024

Abstract

Osteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs 1, 2). Early management is important in order to avoid disability uphold quality of life (Ref. 3). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. 4). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs 5, 6, 7, 8). Established risk factors for the development and progression of OA include increasing age, female, history of trauma and obesity (Ref. 9). Recent studies have also drawn a link between OA and metabolic syndrome, which is characterized by insulin resistance, dyslipidaemia and hypertension (Refs 10, 11).

Keywords

biomarkers, diabetes mellitus, inflammation, metabolism, osteoarthritis

Publication Title

Expert Reviews in Molecular Medicine

Divisions

medicinedept

Funders

Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia (FRGS/1/2021/SKK0/UKM/02/15)

Volume

26

Publisher

Cambridge University Press

Publisher Location

EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND

This document is currently not available here.

Share

COinS