Asymmetric Diels-Alder reaction of chalcone and isoprene mediated by titanium-based complexes
Document Type
Article
Publication Date
4-1-2024
Abstract
The asymmetric Diels-Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels-Alder reaction between chalcone and isoprene. GRAPHICS]
Keywords
4+2] cycloaddition, enantiomeric synthesis, 2-methyl-1, 3-butadiene, trans-chalcone, titanium tetrachloride
Divisions
CHEMISTRY,cenar,nanotechnology
Funders
Universiti Malaya (IIRG003B-2019); (BK044-2017),Universiti Malaya Research Grants
Publication Title
Synthetic Communications
Volume
54
Issue
8
Publisher
Taylor and Francis
Publisher Location
530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA