Impact of elevated IgE in protective immunity and immunopathology of dengue
Document Type
Article
Publication Date
3-1-2024
Abstract
Dengue is a mosquito -transmitted infection endemic in tropical and subtropical locations of the world where nearly half of the world's population resides. The disease may present as mild febrile illness to severe and can even be fatal if untreated. There are four genetically related but antigenically distinct dengue virus (DENV) serotypes. Immune responses to DENV infection are in general protective but under certain conditions, they can also aggravate the disease. The importance of the cellular immune responses and the antibody responses involving IgG and IgM has been well -studied. In contrast, not much has been described on the potential role of hypersensitivity reactions involving IgE in dengue. Several studies have shown elevated levels of IgE in patients with dengue fever, but its involvement in the immune response against the virus and disease is unknown. Activation of mast cells (MCs) and basophils mediated through dengue -specific IgE could result in the release of mediators affecting dengue virus infection. The present review explores the relationships between the induction of IgE in dengue virus infection, and the potential role of MCs and basophils, exploring both protective and pathogenic aspects, including antibody -dependent enhancement (ADE) of infection in dengue.
Keywords
Dengue, IgE, mast cells, ADE, immunity
Divisions
medbio,advanced,tidrec
Funders
Ministry of Higher Education for the Fundamental Research Grant Scheme (FRGS/1/2019/SKK 11/UM/02/4),Higher Institution Centre of Excellence (HICoE) Program (MO002-2019),Long Term Research Grant Scheme (LRGS MRUN/F1/01/2018)
Publication Title
Tropical Biomedicine
Volume
41
Issue
1
Publisher
Malaysian Society of Parasitology and Tropical Medicine
Publisher Location
21-5-2, BLOCK, E, DIAMOND SQUARE, JALAN 3-50, OFF JALAN GOMBAK, KUALA LUMPUR, MALAYSIA