Tumor suppressive effects of GAS5 in cancer cells
Document Type
Article
Publication Date
6-1-2022
Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review arti-cle focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
lncRNA, Growth-arrest specific transcript, 5GAS5, Tumor suppressor, Polymorphism
Divisions
fac_med
Funders
Ministry of Education, Malaysia [Grant No: FRGS/1/2019/STG03/UM/02/4]
Publication Title
Non-coding RNA
Volume
8
Issue
3
Publisher
MDPI