Arboduridine, a hexacyclic caged monoterpenoid indole incorporating cyclohexane, piperidine, and bridged-fused pyrrolidine-tetrahydrofuran moieties
Document Type
Article
Publication Date
5-1-2022
Abstract
A new monoterpenoid indole alkaloid, arboduridine (1), characterized by a hexacyclic cage skeleton, incorporating cyclohexane, piperidine, and bridged-fused pyrrolidine-tetrahydrofuran moieties, was isolated from a Malayan Kopsia species. The structure of the alkaloid was determined based on analysis of the NMR and MS data, while the absolute configuration was established by ECD measurements in conjunction with DFT calculations. A possible biogenetic pathway from a pericine precursor is presented. (c) 2022 Elsevier Ltd. All rights reserved.
Keywords
Kopsia arborea, Alkaloids, NMR, ECD
Divisions
CHEMISTRY
Funders
MOHE Malaysia [Grant No; FRGS/1/2019/STG01/UM/02/23],Universiti Malaya
Publication Title
Tetrahedron Letters
Volume
98
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND