MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Document Type
Article
Publication Date
1-1-2024
Abstract
FOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is influenced by post-translational modifications, altering its subcellular localisation. In addition, FOXO3 can also be regulated directly or indirectly by microRNAs (miRNAs) or vice versa. This review discusses the involvement of various miRNAs in FOXO3-driven cellular responses such as senescence, apoptosis, autophagy, redox and inflammation defence. Given that these responses are linked and influence cell fate, a thorough understanding of the complex regulation by miRNAs would provide key information for developing therapeutic strategy and avoid unintended consequences caused by off-site targeting of FOXO3. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
Keywords
Ageing, Cellular senescence, FOXO3, microRNA, Therapeutic strategy
Divisions
fac_med
Funders
AAALAC [Grant no. IF084-2022],IQ Consortium
Publication Title
Biogerontology
Volume
25
Issue
1
Publisher
Springer Science and Business Media B.V.