Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages

Document Type

Article

Publication Date

1-1-2024

Abstract

Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targeting MD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. © 2024 Future Medicine Ltd.. All rights reserved.

Keywords

flavonoids, Inflammatory responses, Lipopolysaccharides, Macrophages, Monocytes

Publication Title

Future Medicinal Chemistry

Divisions

CHEMISTRY

Funders

Ministry of Higher Education, Malaysia [Grant no. FRGS/1/2022/STG04/UIAM/02/2],International Islamic University Malaysia [Grant no. RMCG20-008-0008]

Volume

16

Issue

1

Publisher

Newlands Press Ltd

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