Erythrocarpines I–N, new limonoids from the barks of Chisocheton erythrocarpus and their neuroprotective effects against hydrogen peroxide in NG108–15 cells
Document Type
Article
Publication Date
1-1-2024
Abstract
A phytochemical study on the bark of Chisocheton erythrocarpus Hiern (Meliaceae) has led to the isolation of six new phragmalin-type limonoids named erythrocarpines I – N (1–6) along with one known limonoid, erythrocarpine F (7). Their structures were fully characterized by spectroscopic methods. The pre-treatment of NG108–15 cells with 1–5, 7 (2 h) demonstrated low to good protective effects against H2O2 exposure; 1 (83.77 ± 1.84 at 12.5 μM), 2 (69.07 ± 2.01 at 12.5 μM), 3 (80.38 ± 2.1 at 12.5 μM), 4 (62.33 ± 1.95 at 25 μM),5 (58.67 ± 1.85 at 50 μM) and 7 (66.07 ± 2.03 at 12.5 μM). Interestingly, 1 and 3 demonstrated comparable protective effects to positive control epigallocatechin gallate (EGCG) with similar cell viability capacity (≈ 80), having achieved that at lower concentration (12.5 μM) than EGCG (50 μM). Collectively, the results suggested the promising use of 1 and 3 as potential neuroprotective agents against hydrogen peroxide-induced cytotoxicity in neuronal model. © 2023 Elsevier B.V.
Keywords
epigallocatechin gallate, hydrogen peroxide, limonoid, 108CC15 cell line, article, bark, cell viability, controlled study, cytotoxicity, drug analysis, drug development, human, neuroprotection, pharmacology
Divisions
CHEMISTRY,cenar
Funders
Malaysia's Ministry of Higher Education (PR002-2019A)
Publication Title
Fitoterapia
Volume
173
Publisher
Elsevier
Additional Information
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