Synthesis and evaluation of antibacterial activity of transition metal-oleoyl amide complexes
Document Type
Article
Publication Date
11-1-2023
Abstract
Recent studies show that some metal ions, injure microbial cells in various ways due to membrane breakdown, protein malfunction, and oxidative stress. Metal complexes are suited for creating novel antibacterial medications due to their distinct mechanisms of action and the variety of three-dimensional geometries they can acquire. In this Perspective, the present study focused on new antibacterial strategies based on metal oleoyl amide complexes. Thus, oleoyl amides ligand (fatty hydroxamic acid and fatty hydrazide hydrate) with the transition metal ions named Ag (I), Co (II), Cu (II), Ni (II) and Sn (II) complexes were successfully synthesized in this study. The metals- oleoyl amide were characterized using elemental analysis, and fourier transforms infrared (FTIR) spectroscopy. The antibacterial effect of metals- oleoyl amide complexes was investigated for Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) by analysing minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and scanning electron microscopy (SEM). The results showed that metal-oleoyl amide complexes have high antibacterial activity at low concentrations. This study inferred that metal oleoyl amide complexes could be utilised as a promising therapeutic antibacterial agent.
Keywords
Transition metals, Metal-fatty hydroxamic acids, Metal-fatty hydrazide hydrate, Antibacterial activity
Divisions
medbio,CHEMISTRY
Funders
Ministry of Higher Education & Scientific Research (MHESR),Fundamental Research Grant Scheme (FRGS) (FP105-2020) ; (FP052-2016),Universiti Malaya (PG335-2016A)
Publication Title
Bioorganic Chemistry
Volume
140
Publisher
Elsevier
Publisher Location
525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA