Periodontitis and progression of gastrointestinal cancer: Current knowledge and future perspective
Document Type
Article
Publication Date
10-1-2023
Abstract
Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis.
Keywords
Colorectal cancer, Periodontitis, IBD, Porphyromonas gingivalis, Malignancy
Divisions
restoreden
Funders
None
Publication Title
Clinical & Translational Oncology
Volume
25
Issue
10
Publisher
Springer Int Publ Ag
Publisher Location
GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND